MovDisordV3, Main, Exploration, bibRecord, 005824

Striatal dihydroxyphenylalanine decarboxylase and tyrosine hydroxylase protein in idiopathic Parkinson's disease and dominantly inherited olivopontocerebellar atrophy

Identifieur interne : 005824 ( Main/Exploration ); précédent : 005823; suivant : 005825

Striatal dihydroxyphenylalanine decarboxylase and tyrosine hydroxylase protein in idiopathic Parkinson's disease and dominantly inherited olivopontocerebellar atrophy

Auteurs : Xiao-Hui Zhong [Canada] ; John W. Haycock [États-Unis] ; Kathleen Shannak [Canada] ; Yves Robitaille [Canada] ; Jonathan Fratkin [États-Unis] ; Arnuf H. Koeppen [États-Unis] ; Oleh Hornykiewicz [Canada, Autriche] ; Kish [Canada]

Source :

Movement Disorders [ 0885-3185 ] ; 1995-01.

RBID : ISTEX:34AD1A9AA121CA42789265D7FF5002FA00623C49

English descriptors

KwdEn :
- Aged, Cerebellar ataxia, Dihydroxyphenylalanine decarboxylase, Dominantly inherited olivopontocerebellar atrophy, Dopa Decarboxylase (analysis), Dopa Decarboxylase (metabolism), Dopamine, Dopamine (analysis), Dopamine (metabolism), Humans, Immunoblotting, Middle Aged, Olivopontocerebellar Atrophies (diagnosis), Olivopontocerebellar Atrophies (enzymology), Parkinson Disease (diagnosis), Parkinson Disease (enzymology), Parkinson's disease, Tyrosine 3-Monooxygenase (analysis), Tyrosine 3-Monooxygenase (metabolism), Tyrosine hydroxylase, Visual Cortex (chemistry).
MESH :
- chemical , analysis : Dopa Decarboxylase, Dopamine, Tyrosine 3-Monooxygenase.
- chemical , metabolism : Dopa Decarboxylase, Dopamine, Tyrosine 3-Monooxygenase.
- chemistry : Visual Cortex.
- diagnosis : Olivopontocerebellar Atrophies, Parkinson Disease.
- enzymology : Olivopontocerebellar Atrophies, Parkinson Disease.
- Aged, Humans, Immunoblotting, Middle Aged.

Abstract

We measured the levels of dopamine, tyrosine hydroxylase (TH) protein, and dihydroxyphenylalanine (DOPA) decarboxylase (DDC) protein in the striatum of 10 patients with idiopathic Parkinson's disease (PD) and 23 patients with dominantly inherited olivopontocerebellar atrophy (OPCA). The levels of dopamine were markedly reduced (2% of control) in the striatum of the patients with PD, whereas striatal dopamine in the patients with OPCA ranged from normal (<60% of control) to moderately reduced (20–60% of control) to severely depleted (<20% of control). Both TH and DDC protein levels were significantly lower than those of the controls in the striatum of all of the patients with PD and in the subgroup of patients with OPCA having severely depleted dopamine. In contradistinction, TH but not DDC protein levels were reduced in those patients with OPCA having moderately reduced dopamine levels. This suggests that in the early stage of nigrostriatal dopamine neurone degeneration, DDC levels may be less susceptible to neurodegenerative influences than is TH synthesis or, alternatively, DDC synthesis may be more aggressively upregulated. Unexpectedly, from the blot immunolabeling analysis an additional DDC‐immunoreactive band of slightly lower apparent molecular mass was detected in two of the patients with PD and in 12 of the patients with OPCA. This additional DDC band, which was not present in any of the control subjects, may reflect posttranslational modification(s) of DDC related to the neurodegenerative process.

Url:

https://api.istex.fr/document/34AD1A9AA121CA42789265D7FF5002FA00623C49/fulltext/pdf

DOI: 10.1002/mds.870100104

Affiliations:

Le document en format XML

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<author><name sortKey="Zhong, Xiao Ui" sort="Zhong, Xiao Ui" uniqKey="Zhong X" first="Xiao-Hui" last="Zhong">Xiao-Hui Zhong</name>
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<author><name sortKey="Haycock, John W" sort="Haycock, John W" uniqKey="Haycock J" first="John W." last="Haycock">John W. Haycock</name>
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<author><name sortKey="Shannak, Kathleen" sort="Shannak, Kathleen" uniqKey="Shannak K" first="Kathleen" last="Shannak">Kathleen Shannak</name>
</author>
<author><name sortKey="Robitaille, Yves" sort="Robitaille, Yves" uniqKey="Robitaille Y" first="Yves" last="Robitaille">Yves Robitaille</name>
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<author><name sortKey="Fratkin, Jonathan" sort="Fratkin, Jonathan" uniqKey="Fratkin J" first="Jonathan" last="Fratkin">Jonathan Fratkin</name>
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<author><name sortKey="Koeppen, Arnuf H" sort="Koeppen, Arnuf H" uniqKey="Koeppen A" first="Arnuf H." last="Koeppen">Arnuf H. Koeppen</name>
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<author><name sortKey="Hornykiewicz, Oleh" sort="Hornykiewicz, Oleh" uniqKey="Hornykiewicz O" first="Oleh" last="Hornykiewicz">Oleh Hornykiewicz</name>
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<author><name sortKey="Shannak, Kathleen" sort="Shannak, Kathleen" uniqKey="Shannak K" first="Kathleen" last="Shannak">Kathleen Shannak</name>
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<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
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<term>Dominantly inherited olivopontocerebellar atrophy</term>
<term>Dopa Decarboxylase (analysis)</term>
<term>Dopa Decarboxylase (metabolism)</term>
<term>Dopamine</term>
<term>Dopamine (analysis)</term>
<term>Dopamine (metabolism)</term>
<term>Humans</term>
<term>Immunoblotting</term>
<term>Middle Aged</term>
<term>Olivopontocerebellar Atrophies (diagnosis)</term>
<term>Olivopontocerebellar Atrophies (enzymology)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (enzymology)</term>
<term>Parkinson's disease</term>
<term>Tyrosine 3-Monooxygenase (analysis)</term>
<term>Tyrosine 3-Monooxygenase (metabolism)</term>
<term>Tyrosine hydroxylase</term>
<term>Visual Cortex (chemistry)</term>
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<term>Dopamine</term>
<term>Tyrosine 3-Monooxygenase</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopa Decarboxylase</term>
<term>Dopamine</term>
<term>Tyrosine 3-Monooxygenase</term>
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<front><div type="abstract" xml:lang="en">We measured the levels of dopamine, tyrosine hydroxylase (TH) protein, and dihydroxyphenylalanine (DOPA) decarboxylase (DDC) protein in the striatum of 10 patients with idiopathic Parkinson's disease (PD) and 23 patients with dominantly inherited olivopontocerebellar atrophy (OPCA). The levels of dopamine were markedly reduced (2% of control) in the striatum of the patients with PD, whereas striatal dopamine in the patients with OPCA ranged from normal (<60% of control) to moderately reduced (20–60% of control) to severely depleted (<20% of control). Both TH and DDC protein levels were significantly lower than those of the controls in the striatum of all of the patients with PD and in the subgroup of patients with OPCA having severely depleted dopamine. In contradistinction, TH but not DDC protein levels were reduced in those patients with OPCA having moderately reduced dopamine levels. This suggests that in the early stage of nigrostriatal dopamine neurone degeneration, DDC levels may be less susceptible to neurodegenerative influences than is TH synthesis or, alternatively, DDC synthesis may be more aggressively upregulated. Unexpectedly, from the blot immunolabeling analysis an additional DDC‐immunoreactive band of slightly lower apparent molecular mass was detected in two of the patients with PD and in 12 of the patients with OPCA. This additional DDC band, which was not present in any of the control subjects, may reflect posttranslational modification(s) of DDC related to the neurodegenerative process.</div>
</front>
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Movement Disorders (revue)

Striatal dihydroxyphenylalanine decarboxylase and tyrosine hydroxylase protein in idiopathic Parkinson's disease and dominantly inherited olivopontocerebellar atrophy

Striatal dihydroxyphenylalanine decarboxylase and tyrosine hydroxylase protein in idiopathic Parkinson's disease and dominantly inherited olivopontocerebellar atrophy

Source :

English descriptors

Abstract

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	Movement Disorders (revue)
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